Inflammation in end-stage renal failure: could it be treated?
نویسنده
چکیده
End-stage renal disease (ESRD) is characterized by an exceptional mortality rate, much of which is the result of cardiovascular disease (CVD). Although traditional risk factors are common in ESRD patients, they may not be sufficient alone to account for the high prevalence of CVD in this condition. Recent evidence demonstrates that chronic inflammation, a non-traditional risk factor which is observed commonly in ESRD patients, may cause malnutrition and progressive atherosclerotic CVD by several pathogenetic mechanisms. The causes of inflammation in ESRD are multifactorial and, while it may reflect underlying CVD, an acute-phase reaction may also be a direct cause of vascular injury by several pathogenetic mechanisms. Available data suggest that pro-inflammatory cytokines play a central role in the genesis of both malnutrition and CVD in ESRD. Thus, it could be speculated that suppression of the vicious cycle of malnutrition, inflammation and atherosclerosis (MIA) would improve survival in dialysis patients. Recent evidence has demonstrated strong associations between inflammation and both increased oxidative stress and endothelial dysfunction in ESRD patients. As there is as yet no recognized, or even proposed, treatment for ESRD patients with chronic inflammation, it would be of obvious interest to study the long-term effect of various anti-inflammatory treatment strategies on the nutritional and cardiovascular status as well as the outcome in these patients.
منابع مشابه
Lactulose efficacy in reduction of nitrogen products,blood potassium and fluid overload in patients with end-stage renal failure ..
Introduction.Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease.Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function.Lactulose is a hyper osmotic agent and as a prebioticplays an important role in regulating serum urea...
متن کاملLactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure.
Abstract Introduction. Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease. Patients with chronic kidney disease (CKD) face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function. Lactulose is a hyper osmotic agent and as a prebiotic could reduce serum urea and p...
متن کاملاتیولوژی و سرنوشت End Stage Renal Ddisease در کودکان تحت همودیالیز مرکز طبی کودکان، 81-1368
Background: Chronic renal failure defines as progressive and irreversible dysfunction of kidneys that could eventually terminated to end stage renal disease (GFR< 10% NL). Because of therapeutic problem and high mortality and morbidity and it ;aposs implication quality of life , ESRD is one of the important dilemma of pediatric medicine . Materials and Methods: In our study 216 patients evaluat...
متن کاملLactulose efficacy in reduction of nitrogen products, blood potassium and fluid overload in patients with end-stage renal failure
Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stagedisease. Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overloadin CKD patients is associated with rapid decline in kidney function. Lactulose is a hyper osmotic agent andas a prebiotic plays an important role in regulating serum urea and potassiu...
متن کاملبررسی شیوع عوارض بیماری مزمن کلیه کودکان و عوامل مرتبط در بیمارستان مفید ، سال های 1393-1392
Background and Objective: The end result of chronic kidney disease, irrespective of the type of kidney disease including progression to kidney failure and its complications as cardiopulmonary disease. The evidence show that recognition and treatment of this disease is often preventive and delay some complications of the disease and prevent the incidence of end stage renal failure. The purpose o...
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ورودعنوان ژورنال:
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
دوره 17 Suppl 8 شماره
صفحات -
تاریخ انتشار 2002